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CRYOMED

Supervision and Monitoring System for Cryobanks

Beyond limits: the power of cryogenics.

Overview

CRYOMED is an advanced system designed to automate and safely supervise all critical operations in cryobanks, biobanks, laboratories and Assisted Reproductive Technology (ART) centers. It delivers efficiency, control, and peace of mind in demanding environments.

Ensuring the safe preservation of biological materials at ultra-low temperatures using liquid nitrogen requires uncompromising standards: maximum sample integrity, the highest levels of safety, and consistent operational reliability. At the same time, minimizing human intervention is essential to protect both processes and personnel.

Built on a hierarchical, modular, and scalable architecture, CRYOMED seamlessly adapts to facilities of any size—from small biobanks to complex, large-scale infrastructures. This flexible configuration enables easy, non-invasive expansion while simplifying maintenance and system upgrades.

Applications

Laboratory

Hospital

Life Science

Veterinary

IVF Centers

Industry

Pharma

Nursing Home

Key Benefits

Simple and flexible system interconnection

The architecture supports flexible interconnection of system components.

Innovation driven by customer needs

CRYOMED is positioned around customer-specific requirements..

Compact, space-efficient design

The brochure identifies compact, space-efficient design as a key benefit.

Real-time monitoring

Continuous supervision provides real-time visibility of connected systems.

Optimized cost efficiency

The system is presented with a focus on optimized cost efficiency.

CRYOMED System Architecture

The CRYOMED architecture combines software supervision, intelligent junction-box devices and wireless temperature monitoring.

NEVALIS JB – Controller

The smart supervision software — Maximum precision, total control

Our software combines smart technology, high operational efficiency, and an intuitive interface to deliver precise, continuous real-time monitoring. A modern, fully customizable solution engineered to seamlessly adapt to the specific needs of any facility.

The Junction Box Controller (JBC) is a modular solution designed to manage complex cryogenic systems with complete reliability. Thanks to continuous supervision and real-time diagnostics, the JBC proactively detects and alerts any anomalies, ensuring safe operation in controlled environments with the highest safety standards.

Key Features

  • Real-time monitoring of the entire system status: cryogenic containers, refrigerators, tanks, cryogenic lines, oxygen probes, environmental sensors, and ventilation systems.
  • Manages the cryogenic line and all connected systems, including ventilation, environmental safety, and the telephone dialer.
  • Historical data trend visualization with CSV export for advanced reporting and analysis.
  • RS485 Multi-Device Bus supports cryogenic containers, refrigerators, incubators, buffer tanks, and pressure switches, enabling parameter monitoring and alarm detection from each node.
  • Designed for seamless integration into existing systems.
  • Interactive dashboard: a customizable and intuitive 3D interface, suitable even for non-technical users.
  • Multilingual interface available in five languages: Italian, English, French, German, and Spanish.
  • Multi-level User Management: Administrator, Power User, and Operator profiles.
  • Cybersecurity: no need to open inbound ports on the server; the NEVALIS server can be deployed on a dedicated PC, virtual machine, or in the cloud.
  • Secure access control via RFID badges, with full traceability of all operations.
  • SCADA Supervision via LAN using Ethernet in a client-server architecture.
  • Remote supervision via LAN/WAN, compatible with VPNs, virtualized environments, and hospital cloud servers.
  • Centralized alarm handling with history tracking and notification delivery.
  • Quick and intuitive switching from automatic operation to manual mode.

Technical Specifications

Technical specification
Data
Power Supply
6-35 V DC / 5-24 V AC
Digital Inputs
24
Analogical Inputs
Analogical Inputs 12 x (4-20 mA)
Digital output
40 free indipendent contacts
Managed solenoid valves
7 + forced ventilation
7 + forced ventilation
4 x Pt100 / Pt1000
4 x Pt100 / Pt1000
3 x RS485 (2/4 wires) – Modbus RTU
Network Connectivity
1 x LAN (Ethernet)
1 x LAN (Ethernet)
Color Touch Screen Display 7”
Service Port
1 x USB-C
Storage
SD Card
Storage
Manual safety E-Stop button + key switch + solenoid valve selectors
Acoustic Signal
Built-in Buzzer

JB – Device

Intelligent Connectivity for Total Integration

The Junction Box Device (JBD) acts as an intelligent hub for the integration of a wide range of laboratory and storage equipment, including cryogenic containers, refrigerators, incubators, sensors, buffer tanks, and more.

Key Features

  • Advanced Multi-Parameter Monitoring: supports both MODBUS serial communication and dedicated analog and digital inputs, providing complete visibility over all critical parameters.
  • Flexibility and Interoperability: seamless integration with existing supervision systems, adapting effortlessly to different network architectures.
  • Multi-state signaling: controls tri-color signal lights, buzzers, and safety devices (solenoid valves and forced ventilation).
  • Active Safety: autonomously manages alarm conditions, providing real-time localized audible and visual alerts independent of the JBC.
  • Universal Protocol Bridge: converts proprietary manufacturer protocols into standard Modbus RTU.

Technical Specifications

Technical specification
Data
Power Supply
6-35 V DC / 5-24 V AC
Digital Inputs
8
Analogical Inputs
4 × (4–20 mA)
Temperature Inputs
4 × Pt100 / Pt1000
Digital Output (free contacts)
8
Relè Output
3 (solenoid valve, ventilation, buzzer)
Communication Interfaces
2 × RS485 (2/4 wires)
RS485 1
To JBC — dedicated preferential bus (Slave mode)
Network Connectivity
1 × LAN Ethernet
Display
Color Touch Screen 4.3”
Service Port
2 × USB
Acoustic Signal
Built-in Buzzer
Local alarm autonomy
Yes – Independent from JBC
Max. supported probes
8 (via radio expansion module)

JB – Device Oxygen

Advanced Oxygen Monitoring & Safety Control

The Junction Box Device Oxygen is an advanced monitoring and safety solution designed for the continuous detection of oxygen levels, temperature, and humidity in critical environments, via MODBUS connection or analog 4–20 mA signals to environmental sensors.

Key Features

  • Advanced Multi-Parameter Monitoring.
  • Flexibility and Interoperability with existing supervision systems.
  • Multi-state signaling through tri-color signal lights, buzzers, solenoid valves and forced ventilation.
  • Active Safety with autonomous management of pre-alarm and critical alarm thresholds.

Technical Specifications

Technical specification
Data
Power Supply
6-35 V DC / 5-24 V AC
Digital Inputs
8
Analogical Inputs
4 × (4–20 mA)
Temperature Inputs
4 × Pt100 / Pt1000
Relè Output
3 (signal light, ventilator, solenoid valve)
RS485 1
To JBC — dedicated preferential bus (Slave mode)
RS485 2
To Modbus sensor O₂/CO₂ (Master)
Network Connectivity
1 × LAN Ethernet
Display
Color Touch Screen 4.3”
Service Port
USB
Acoustic Signal
Built-in Buzzer
Local alarm autonomy
Yes – Independent from JBC

Smart-T

Simplified Bus Distribution

Smart–T is an RS485 concentrator and repeater with power distribution over RJ45, designed to streamline cabling and bus distribution.

  • Four RJ45 connectors and integrated power supply allow up to three JBD modules to be connected using a single JBC bus, delivering both communication signal and power through the same network cable.
  • Supports daisy-chaining of multiple devices, ensuring signal integrity even over long distances.

CryoWave

Effortless Temperature Control Anywhere

CryoWave is a wireless temperature probe designed for monitoring dewars, refrigerators, and incubators in cryogenic environments, laboratories, IVF centers, cleanrooms, and sterile environments.

Key Features

  • Communicates via 868 MHz radio directly with the JBD, enabling the management of up to 8 PT100/PT1000 probes simultaneously.
  • Battery life of up to 1 year, rechargeable via USB or wirelessly, with no need to disassemble the device.
  • No wiring required, eliminating exposed cables in sterile environments.
  • Flexible positioning without system downtime.
  • Multicolor LED indicating operating status, battery level, and alarm conditions.

Technical Specifications

Technical specification
Data
Radio communication
868 MHz FSK
Max probes per JBD
8 via radio expansion module
Temperature probe
PT100 / PT1000
Resolution
+/-0.2 C
Operating temperature range
-10 / +50 C
Alternative input
4-20 mA (alternative to PT100/PT1000)
Digital input
2
Output
1 free contact
Power supply
Rechargeable battery
Battery life
~1 year
Charging
USB / Wireless (Qi)
Status indication
Multicolour LED (status, alarm, battery)
Alarm management
Configurable thresholds with automatic transmission to JBD
Dimensions
55 x 35 x 15 mm

Looking for a Cryogenic Monitoring Solution?

S.I.G. SIGRA IMPRIM GROUP is an Italian company specialized in the development of advanced solutions for technical, pure, ultra-pure, and cryogenic gases, with a strong focus on quality, innovation, and customer satisfaction.

The company offers services from initial consultation and design to installation, revamping, and after-sales support for industrial, medical, life sciences, laboratory, and research applications.

Contact Us